Single Cell DNA Sequencing – from Analog to Digital

Larry Xi

Digenomix Corp, South San Francisco, California, USA. Email:

*Corresponding author: Larry Xi. 7000 Shoreline Court #100, South San Francisco, CA 94080. Email:

Citation: Larry Xi. Single-Cell DNA Sequencing: From Analog to Digital. Cancer Research Frontiers. 2017; 3(1): 161-169. doi: 10.17980/2017.161

Copyright: @ 2017 Larry Xi. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Competing Interests: Larry Xi is CEO and Founder of Digenomix, which commercializes transposon barcoded (TnBC) library methodology.

Received Jan 30, 2018; Revised Mar 23, 2018; Accepted Mar 27, 2018. Published Apr 10, 2018

Abstract:

Single-cell DNA sequencing is emerging as a powerful and essential tool for interrogating heterogeneous tissues such as cancer samples. Its full potential in cancer research and diagnostics will only be realized when digital methodology is implemented and the cost is significantly reduced.

Keywords: single-cell, NGS, TnBC, heterogeneity, digital, UFI