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Research Article

Cancer Research Frontiers. 2018; 4(1): 45-59. doi: 10.17980/2018.45

Decreased levels of the serum inflammatory biomarkers, sGP130, IL-6, sCRP and BAFF, are associated with increased likelihood of AIDS related Kaposi’s sarcoma in men who have sex with men

Rachel Bolanos1, Otoniel Martinez-Maza 1, 2, 3, 4, Zuo-Feng Zhang1, 3, Shehnaz Hussain1, 5, Mary Sehl6, 8, Janet S. Sinsheimer 7,8, 9, Gypsyarn D’Souza10, Frank Jenkins11, Steven Wolinsky12, Roger Detels1

1Department of Epidemiology, Fielding School of Public Health, UCLA, Los Angeles, CA 2Departments of Obstetrics and Gynecology, and Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, UCLA, Los Angeles, CA 3Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 4UCLA AIDS Institute, UCLA, Los Angeles, CA 5Department of Medicine and Comprehensive Cancer Center, Cedars-Sinai Medical Center, West Hollywood, CA 6Department of Medicine, Division of Hematology/Oncology, AIDS Institute, UCLA, Los Angeles, California 7Department of Human Genetics, UCLA, Los Angeles, California 8Biomathematics, David Geffen School of Medicine, UCLA, Los Angeles, California 9Department of Biostatistics, School of Public Health, UCLA, Los Angeles, California 10Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 11University of Pittsburgh Cancer Institute, Pittsburgh, PA 12Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago Illinois.

 

*Corresponding author: Rachel Bolanos, 4430 Overland Ave. #3, Culver City, CA 90230. Phone : 619-337-4748. Email : rsking1286@gmail.com

Citation: Rachel Bolanos, et al. Decreased levels of the serum inflammatory biomarkers, sGP130, IL-6, sCRP and BAFF, are associated with increased likelihood of AIDS related Kaposi’s sarcoma in men who have sex with men. Cancer Research Frontiers. 2018; 4(1): 45-59. doi: 10.17980/2018.45

Copyright: @ 2018 Rachel Bolanos, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Competing Interests: The authors declare no competing financial interests.

Received July 26, 2018; Revised Oct 4, 2018; Accepted Oct 11, 2018. Published Dec 5, 2018.

 

Abstract:

AIDS-related Kaposi’s sarcoma (AIDS-KS) risk remains substantially elevated compared with the general population, even among patients who receive effective combination antiretroviral therapy. This study investigated the role of inflammatory and immune activating biomarkers in AIDS-KS in men who have sex with men in the Multicenter AIDS Cohort study between 1984 and 2010. Concentrations of 24 serum biomarkers; IL-1β, IL-2, Il-6, IL-8, IL-10, IL-12p70, sGP130, sIL-2Rα, sIL-6R, eotaxin, MCP-1, MCP4, MIP 1β, TARC, BLC-BCA1, IP-10, GM-CSF, IFN-γ, BAFF, sCD14, CD27, sTNFR-2, sCRP, and TNF-α were tested longitudinally in 1,501 men. The concentrations of each biomarker were compared between AIDS-KS cases and controls at multiple time points, 0-1 years, 1-2 years, 2-3 year, 3-5 years and over 5 years, prior to KS diagnosis or study termination, using univariate non-parametric Kruskal-Wallis tests and logistic regression, adjusted for HBV and HCV co-infection, race/ethnicity, age at last visit, education, smoking and CD4+ cell count. In univariate analyses, concentrations of four markers were consistently higher in cases; sIL-2Rα, IP-10, sTNFR-2, MCP-1, and five were higher in controls; GM-CSF, IL-6, MIP-1β, sCRP, sGP130. In the adjusted models concentrations of four markers were significantly inversely associated with AIDS-KS risk including sGP130 (OR=0.14, 95% CI = 0.03-0.73, BAFF (OR=0.60, 95% CI =0.16-0.90), sCRP (OR=0.61, 95% CI = 0.43-0.87) and IL-6 (OR=0.51, 95% CI = 0.35-0.76). These results support a role for markers of immune activation and inflammation in AIDS-KS and may highlight pathways to be targeted for risk stratification or therapeutics.

Key Words: AIDS, Kaposi’s sarcoma, inflammatory biomarkers

 

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