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Review

Cancer Research Frontiers. 2016 Sept; 2(3): 396-410. doi: 10.17980/2016.396

Clinicopathological features and surgical outcomes of cholangiolocellular carcinoma: a systematic review

Teppei Tokumaru1, Takehiro Okabayashi1*, Yasuo Shima1, Yuichi Saisaka1, Tatsuaki Sumiyoshi1, Akihito Kozuki1, Kenta Sui1, Manabu Matsumoto2, Yasuhiro Hata3, Yoshihiro Noda3, Sojiro Morita3, Akihito Nishioka3, and Jun Iwata2.

1Department of Gastroenterological Surgery,

2Department of Diagnostic Pathology, and

3Department of Radiology, at Kochi Health Sciences Center.

 

*Corresponding author: Takehiro Okabayashi, MD, PhD. Department of Gastroenterological Surgery, Kochi Health Sciences Center. 2125-1 Ike, Kochi-City, Kochi 781-8555, Japan. Telephone: +81- 88-837-3000; Fax: +81- 88-837-6766; E-mail: tokabaya@gmail.com

Citation: Teppei Tokumaru, et al. Clinicopathological features and surgical outcomes of cholangiolocellular carcinoma: a systematic review. Cancer Research Frontiers. 2016 Sept; 2(3): 396-410. doi: 10.17980/2016.396

Copyright: @ 2016 Teppei Tokumaru, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Competing Interests: The authors declare no competing financial interests.

Received Sept 29, 2016; Revised Nov 10, 2016; Accepted Dec 2, 2016. Published Dec 15, 2016

 

ABSTRACT

Background: Colangiolocellular carcinoma (CoCC) is a rare type of primary malignant liver tumor.

Patients and methods: We searched computed medical databases, ranging from 1959 to 2015, which described surgical resections of CoCCs. The clinicopathological data were evaluated for its association with hepatic CoCC, along with the prognosis for each patient and the surgical outcomes described in the case report.

Results: We obtained clinicopathological data for 75 patients (46 men and 29 women), with a mean age of 64 years (range, 15-84 years), who had undergone surgical resections for CoCCs. Although CoCCs have similar clinicopathological features to hepatocellular carcinomas and/or cholangiocarcinomas, the treatment strategies in patients with CoCCs are identical to those used to treat other primary neoplasms of the liver. The immunohistochemical features of CoCC also included testing positive for epithelial membrane antigen. The overall 1-, 3-, and 5-year survival rates after surgery, for 75 cases with available data, were 92.4%, 65.9%, and 60.8%, respectively.

Conclusions: To determine the best management strategy for this tumor and to improve the accuracy of prognosis for patients, we aim to continue to collect and analyze the epidemiological and pathological data for CoCCs.

Key words: Cholangiolocellular carcinoma, liver, surgery, outcome 

 

 

 

 

 

 

 

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