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Review

Cancer Research Frontiers. 2016 Sept; 2(3): 380-395. doi: 10.17980/2016.380

Anti‐inflammatory Dietary Supplements in the Chemoprevention of Oral Cancer.

Shri Hari1*, Vijeev Vasudevan1, Soundarya Kasibhotla1, Deepa Reddy1, Manjunath Venkatappa1, Devaraju Devaiah1.

1Department of Oral Medicine and Radiology, Krishnadevaraya College of Dental Sciences and Hospital, Bangalore, Karnataka, India. 

*Corresponding author: Shri Hari, Assistant Professor, Department of Oral Medicine and Radiology, Krishnadevaraya College of Dental Sciences and Hospital, Bangalore-562157, Karnataka, India. Email: drshrihariomr@gmail.com. Telephone: 91-9844386188.

Citation: Shri Hari, et al. Anti-inflammatory Dietary Supplements in the Chemoprevention of Oral Cancer. Cancer Research Frontiers. 2016 Sept; 2(3): 380-395. doi: 10.17980/2016.380

Copyright: @ 2016 Shri Hari, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Competing Interests: The authors declare no competing financial interests.

Received July 16, 2016; Revised Oct 28, 2016; Accepted Nov 18, 2016. Published Dec 15, 2016

 

ABSTRACT

Oral cancer is the most serious and growing problem now-a-days in many parts of the world. When grouped with pharyngeal cancer, it is the sixth most common cancer globally. The major risk factors being cigarette smoking that includes tobacco, alcohol abuse and viral infections such as HPV, lead to this condition by inducing inflammatory changes in the oral cavity. Inflammation, a crucial, complex host defense against biologic, chemical, physical and endogenous irritants, is considered as the seventh hallmark of cancer involved in all the stages of carcinogenesis, from initiation, progression to invasion. Inflammatory cells such as macrophages, mast cells and lymphocytes produce several tumor inducing substances such as IL1β, IL-6, TNF-α, NF-κB, MMPs, COX-2 which induce remodeling of extracellular matrix components, inhibit apoptosis resulting in immortalization of tumor cells. Although there have been significant advances in cancer therapeutic modalities, available anti-tumor drugs display limited efficacy and sometimes carry a risk of severe adverse side effects. To address this issue, a number of epidemiological examinations in human populations and experimental animal studies provide evidence that certain dietary supplements such as Curcumin, Epigallocatechin gallate, Resveratrol, etc, suppress the progression of cancer through the inhibition of inflammatory cascade and also modulation of various signaling pathways implicated in the cancer initiation, promotion and progression. In this review article, we summarize the potential role of various anti-inflammatory dietary supplements and their possible chemopreventive mechanisms against oral cancer.

Key words– Inflammation, Oral cancer, Curcumin, Chemoprevention, Reactive oxygen species, Reactive nitrogen species, Omega-3 fatty acids, Epigallocatechingallate (EGCG), Resveratrol, Beta carotene, Lycopene, Vitamin D, cytokine, Antioxidant, Anthocyanins, Genstein, COX-2, NF-kB, STAT-3, TGF-Beta.

 

 

 

 

 

 

 

 

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