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Review

Cancer Research Frontiers. 2016 May; 2(2): 200-225. doi: 10.17980/2016.200

Chronic Inflammation and Carcinogenesis – Emerging Role of Chronic Inflammatory Periodontal Disease

Vishakha Grover1*, Anoop Kapoor2, Komal Sehgal3, Gagandeep Kaur4

1Department of Periodontics & Oral Implantology, Dr. H. S. Judge Institute Of Dental Sciences, Chandigarh, India.

2Department of Periodontics & Oral Implantology, Sukhmani Dental College, Dist. SAS nagar, Mohali (Punjab), India.

3 Department of Prosthodontics, H. S. Judge Institute Of Dental Sciences, Chandigarh, India.

4Department of Periodontics & Oral Implantology, National Dental College & Hospital, Gulabgarh, Derabassi, Dist. SAS nagar, Mohali (Punjab), India.

 

*Corresponding author: Dr. Vishakha Grover1, MDS, Associate Professor of Periodontology, Department of Periodontics & Oral Implantology, Dr. H. S. Judge Institute Of Dental Sciences, Sector-25, Panjab University ,Chandigarh, India. Phone: +91-9814277780; Email: vishakha_grover@rediffmail.com

Citation: Vishakha Grover, et al. Chronic Inflammation and Carcinogenesis – Emerging Role of Chronic Inflammatory Periodontal Disease. Cancer Research Frontiers. 2016 May; 2(2): 200-225. doi: 10.17980/2016.200

Copyright: @ 2016 Vishakha Grover, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Competing Interests: The authors declare no competing financial interests.

Received Oct 24, 2015; Revised Feb 4, 2016; Accepted Feb 13, 2016. Published Apr 30, 2016

 

ABSTRACT

With exponential increase in the number of cases of cancers worldwide in recent past, it is imperative to enhance our understanding about the etiologic and risk factors associated with this seriously morbid condition. Increasing attention has been focussed on chronic infections and inflammatory diseases, implicating a role in carcinogenesis, particularly in developing countries. Periodontal disease is a bacterially induced chronic inflammatory process that affects tooth supporting connective tissue and alveolar bone in the oral cavity, potentially leading to tooth loss. The concept of these diseases as localized entities affecting only the teeth and supporting apparatus has been revised lately, in the light of mounting evidence of periodontal infection’s influence on chronic inflammatory disease states. Periodontal disease has been linked to several systemic conditions like cardiovascular diseases, diabetes mellitus, adverse pregnancy outcomes, obesity and cancers, yet underlying mechanisms are still elucidating. The focus of this review article will be an in depth discussion of the role of chronic inflammation, particularly chronic periodontal inflammation in causation or association of human cancers and discussion of possible biological mechanisms involved.

KEYWORDS : Cancer; Periodontal disease; Inflammation; Carcinogenesis

 

 

 

 

 

 

 

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