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Review

Ellagic Acid: A potent Radio-sensitizer in Cancer Radiotherapy

Vidhula Ahire1*, Kaushala Prasad Mishra2, Gauri Kulkarni1

1 School of Basic Medical Science, University of Pune, Ganeshkhid. Pune-411007. India.

2 Foundation for Education and Research, India and BM International Research Centre, 504, Neelyog Residency CHS Ltd, K-1,Pant Nagar, Ghatkopar (East), Mumbai 400 075. India.

 

*Corresponding author: Vidhula Ahire, PhD, School of Basic Medical Science, University of Pune, Ganeshkhid. Pune-411007. India. Email: vidhula4@gmail.com

Citation: Vidhula Ahire, et al. Ellagic Acid: A potent Radio-sensitizer in Cancer Radiotherapy. Cancer Research Frontiers. 2016 May; 2(2): 141-155. DOI: 10.17980/2016.141

Copyright: @ 2016 Vidhula Ahire, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Competing Interests: The authors declare no competing financial interests.

Received Oct 31, 2015; Revised Jan 9, 2016; Accepted Jan 16, 2016. Published Apr 22, 2016

 

Abstract:

The cytotoxic effect of radiotherapy of cancer is limited due to commonly observed radio-resistance in the clinic. It is, therefore, necessary to develop new strategies to enhance the radiosensitivity of tumor cells by combining therapeutic drugs with optimized radiation doses to improve the treatment outcome. Over the years, research has gained momentum in studying various herbal drugs that have the potential to sensitize tumor cells to ionizing radiation. Herbal drugs possess the property of non-toxic doses to higher concentrations and thereby minimize the undesirable side effects. Our lab recently reported the com­bined effects of radiation and ellagic acid (EA) in generation of increasing ROS as a function of radiation dose in HeLa thereby exhibiting the radiosensitizing effect. This article reviews the mechanism of action of EA involving ROS, cell cycle arrest, apoptosis and activation of signaling molecular cascade as observed in radiosensitization of some tumor cell lines.  These studies suggest its potential usefulness in clinics for improving cancer radiotherapy which works by the mechanism of increasing the oxidative stress through generation of ROS in cancer cells.

Keywords: Radiosensitiser, Cancer, Radiation therapy, Ellagic Acid

 

 

 

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