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Review

Cancer Research Frontiers. 2015 Sep; 1(3): 303-318. DOI: 10.17980/2015.303

Silibinin in cancer therapy: A promising prospect

Prabha Tiwari1and Kaushala Prasad Mishra*2

1 Radiological Physics and Advisory Division, Bhabha Atomic Research Centre, Mumbai – 400085, India. Present address: National Institutes of Biomedical Innovation, Health and Nutrition, 7-6-8, Saito Asagi, Ibaraki, Osaka 567-0085, Japan.

2 Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai – 400085, India. Present address: President, Foundation for Education and Research, 504 Neelyog Residency, K-1, Mumbai 400075 India.

 

*Corresponding author: Prof. Kaushala Prasad Mishra, Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai – 400 085, India. E-mail: mishra_kaushala@rediffmail.com, mishradrlp@gmail.com

Citation: Prabha Tiwari, et al. Silibinin in cancer therapy: A promising prospect. Cancer Research Frontiers. 2015 Sep; 1(3): 303-318. DOI: 10.17980/2015.303

Copyright: @ 2015 Prabha Tiwari, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Competing Interests: The authors declare that there are no competing interests.

Received Sept 1, 2015; Revised Dec 17, 2015; Accepted Dec 25, 2015. Published Dec 31, 2015

 

 

Abstract

The potential anti-cancer properties of natural plant compounds have elicited widespread interest in recent times since it is believed that they can substantially contribute to the development of newer and more effective anti-cancer therapies. Silibinin, a natural flavonoid, has demonstrated chemopreventive properties against many cancer types. A deeper understanding of the signaling pathways modulated by silibinin is important to realize its potential in developing targeted cancer therapies. This review summarizes the recent advances in understanding the molecular mechanisms of silibinin-induced apoptosis in various cancer types.

Keywords: Silibinin, Natural-plant-compound, anti-cancer-compound, Chemotherapeutic-agent, Apoptosis

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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