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Case Report

Cancer Research Frontiers. 2015 Sep; 1(3): 262-267. doi: 10.17980/2015.262

Epstein-Barr virus negative lymphoepithelial carcinoma of parotid gland – a case report with review of literature

Mary Yang1[*]

 1Assistant Professor of Pathology & Laboratory Medicine, UT Health Science Center at Houston, 6431 Fannin Street, Houston, Texas 77030; Department of Pathology, LBJ General Hospital, 5656 Kelley Street, 3PA 93002A, Houston, Texas 77026

 

*Corresponding author: Mary Yang, M.D., FRCPath, FCAP. Department of Pathology, LBJ General Hospital, 5656 Kelley Street, 3PA 93002A, Houston, Texas 77026. Tel: 713-566-5710; Fax: 713-440-1394; E-mail: mary.y.yang@uth.tmc.edu

Citation: Mary Yang. Epstein-Barr virus negative lymphoepithelial carcinoma of parotid gland – a case report with review of literature. Cancer Research Frontiers. 2015 Sep; 1(3): 262-267. doi: 10.17980/2015.262

Copyright: @ 2015 Mary Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Competing Interests: The author declares that there are no competing interests.

Received: August 12, 2015; Revised October 12, 2015; Accepted October 17, 2015.

 

Abstract

Background: Primary lymphoepithelial carcinoma (LEC) of salivary gland is a rare tumor with strong racial and geographical predilection among Eskimos and Orientals in Greenland and Asia, and with strong association with Epstein-Barr virus (EBV). So far, only about 4 cases of EBV negative LEC of salivary gland were reported in the non-endemic area in non-predilected ethnic groups in the English literature. Case report: A 41 year old Hispanic female presented with right parotid mass. Fine needle aspiration of mass showed only lymphoid cells. Incisional biopsy showed anaplastic carcinoma cells with dense stromal lymphoplasmacytic infiltration, consistent with lymphoepithelial carcinoma. In-situ-hybridization (ISH) for EBV-encoded small RNAs (EBER) was negative. Discussion: The author reported a case of EBV negative LEC of salivary gland in a non-endemic area. The observation suggested that EBV may be an important contributing factor, but not a necessary factor in the pathogenesis of LEC of parotid gland. Other factors such as environmental and genetic predisposition may have a contributing role in the pathogenesis of the tumor. Additional studies in non-endemic areas will be necessary to clarify the pathogenesis.

Key words: lymphoepithelial carcinoma; parotid gland; Epstein-Barr virus (EBV); parotid tumor

 

 

 

 

 

 

 

 

 

 

 

 

 

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