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Review

Cancer Research Frontiers. 2015 Apr; 1(2): 138-148. doi: 10.17980/2015.138

New Insights into Laryngeal Squamous Cell Carcinoma: Cancer Stem-Like Cells

Esra Guzel1, Omer Faruk Karatas2, Mete Emir Ozgurses1, Mustafa Ozen1,3*

 

1Department of Molecular Biology and Genetics, Biruni University, Istanbul, Turkey.

2Molecular Biology and Genetics Department, Erzurum Technical University, Erzurum, Turkey.

3Department of Pathology & Immunology Baylor College of Medicine, Houston, TX, 77030, USA.

 

*Corresponding author: Dr. Mustafa Ozen, Department of Medical Genetics/Molecular Biology and Genetics, Biruni University, 10. Yil Caddesi Protokol Yolu No: 45 34010 Topkapi, ─░stanbul, Turkey. Tel: +90 212 444 82 76 Fax: +90 212 416 46 46. E-mail: mozen@bcm.edu

Citation: Guzel E, et al. New Insights into Laryngeal Squamous Cell Carcinoma: Cancer Stem-Like Cells. Cancer Research Frontiers. 2015 Apr; 1(2): 138-148. doi: 10.17980/2015.138

Copyright: @ 2015 Guzel E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Competing Interests: The authors declare that they have no competing interests.

Received February 3, 2015; Revised March 28, 2015; Accepted April 15, 2015.

 

 

Abstract

The Cancer Stem-Like Cells (CSLCs) are cells with tumorigenic potential, which are involved in initiation, progression and spread of the tumor. Recent evidences in the last decade have suggested the existence of CSLCs in distinct types of tumors such as lung, brain, breast, prostate, colon, head and neck, ovarian and larynx cancers. They are identified by their tissue specific stem cell-like properties including self-renewal and having potential to differentiate.

Laryngeal squamous cell carcinoma (LSCC), originating from laryngeal epithelial tissue, is one of the most commonly diagnosed malignancies among the head and neck tumors worldwide. LSCC is frequently diagnosed among middle-aged people and its incidence has been reported to increase each year. Therapeutic options mostly cannot give positive clinical response especially for the advanced LSCC cases. LSCC is still one of the important causes of cancer deaths, particularly in men, worldwide, although the technologies in detection and diagnosis of LSCC have been significantly improved recently.

In this review, we have summarized the most current literature to understand the functions and roles of CSLCs in human LSCC. We believe that this review will contribute to knowledge of scientist not only working in LSCC field, but also studying the CSLCs in other cancers and diseases, and will help elucidating the roles of CSLCs implicated in LSCC initiation, development, progression, and chemo-radioresistance.

Key Words: Laryngeal squamous cell carcinoma; cancer stem cell; CD133

 

 

 

 

 

 

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