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Special Report

Cancer Research Frontiers. 2015 Feb; 1(1): 104-118. doi: 10.17980/2015.104

The Lymphedema Evaluation in Gynecological cancer Study (LEGS): design of a prospective, longitudinal, cohort study

Tracey DiSipio1,2*, Monika Janda1,2, Sandra C. Hayes1,2, Hildegard Reul-Hirche3, Leigh C. Ward4, the LEGS study investigators6, Andreas Obermair5

 
1 School of Public Health and Social Work, Queensland University of Technology, Brisbane, Queensland, Australia (t.disipio@qut.edu.au; m.janda@qut.edu.au; sc.hayes@qut.edu.au)
2 Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia
3 Royal Brisbane and Women’s Hospital, Physiotherapy, Brisbane, Queensland, Australia (Hildegard.Reul-Hirche@health.qld.gov.au)
4 School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia (l.ward@uq.edu.au)
5 Royal Brisbane and Women’s Hospital, Queensland Centre of Gynecological Cancer, Brisbane, Queensland, Australia (ao@surgicalperformance.com)
6 The LEGS study clinician investigators: Jonathan Carter, Naven Chetty, Alex Crandon, Andrea Garrett, Russell Land, Marcelo Nascimento, James L Nicklin, Lewis Perrin, Michael Quinn. Address: Royal Brisbane and Women’s Hospital, Queensland Centre of Gynecological Cancer, Brisbane, Queensland, Australia (Andrea Garrett, Russell Land, James L Nicklin); Mater Private Hospital, South Brisbane, Queensland, Australia (Naven Chetty, Lewis Perrin); Pindara Private Hospital, Gold Coast, Queensland, Australia (Marcelo Nascimento); Central Clinical School, The University of Sydney, New South Wales, Australia (Jonathan Carter); Queensland Health, Royal Brisbane and Women’s Hospital, Brisbane, Queensland, Australia (Alex Crandon); The Royal Women’s Hospital, Victoria, Australia (Michael Quinn).

* Corresponding author: Dr. Tracey DiSipio, School of Public Health and Social Work, Queensland University of Technology. Victoria Park Road, Kelvin Grove QLD 4059 Australia. Phone: 617 3138 9674; Fax: 617 3138 3130. Email: t.disipio@qut.edu.au

Citation: DiSipio T, et al. The Lymphedema Evaluation in Gynecological cancer Study (LEGS): design of a prospective, longitudinal, cohort study. Cancer Research Frontiers. 2015 Feb; 1(1): 104-118. doi: 10.17980/2015.104

Copyright: @ 2015 DiSipio T. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Competing Interests: Author Leigh C. Ward provides consultancy services to ImpediMed Ltd. ImpediMed had no input into the design or execution of this study or in the preparation of this manuscript. All the other authors declare that they have no competing interests.

Received December 4, 2014; Revised February 23, 2015; Accepted February 28, 2015.

 

ABSTRACT

Background: The Lymphoedema Evaluation in Gynecological cancer Study (LEGS) was a longitudinal, observational, cohort study prospectively evaluating the incidence and risk factors of lower-limb lymphedema after treatment for gynecological cancer. Here we describe the study protocol and characteristics of the sample.

Methods: Women with a newly diagnosed gynecological cancer between June 1, 2008 and February 28, 2011, aged 18 years or older, and treated at one of six hospitals in Queensland, Australia, were eligible. Lymphedema was assessed by circumference measurements, bioimpedance spectroscopy, and self-reported swelling. LEGS incorporated a cohort of patients requiring surgery for benign gynecological conditions for comparison purposes. Data were collected prior to surgery and at regular intervals thereafter up to 2-years post-diagnosis.

Results: 546 women participated (408 cancer, 138 benign), with a 24-month retention rate of 78%. Clinical and treatment characteristics of participants were similar to the Queensland gynecological cancer population, except for a higher proportion of early-stage cervical cancers recruited to LEGS compared with Queensland proportions (89% versus 55%, respectively).

Discussion: Few imbalances were observed between participants with complete and incomplete follow-up data. The prospective design and collection of objective and patient-reported outcome data will allow comprehensive assessment of incidence and risk factors of lower-limb lymphedema.

Keywords: cohort; gynecological cancer; longitudinal; lymphedema; observational; prospective.

 

 

 

 

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