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Review

Cancer Research Frontiers. 2017; 3(1): 83-111. doi: 10.17980/2017.83

Prostate Cancer under the Light of Tumor Cells-derived Extracellular Vesicles

Irène Tatischeff*

Honorary CNRS (Centre National de la Recherche Scientifique, Paris, France) and UPMC (Université Pierre et Marie Curie, Paris, France) Research Director; Founder of RevInterCell (www.revintercell.com), a Scientific Consulting Service, Orsay, 91400, France.

 

*Corresponding author: Dr. I. Tatischeff. E-mail:

Citation: Irène Tatischeff. Prostate Cancer under the Light of Tumor Cells-derived Extracellular Vesicles. Cancer Research Frontiers. 2017; 3(1): 83-111. doi: 10.17980/2017.83

Copyright: @ 2017 Irène Tatischeff. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Competing Interests: The author declares no competing financial interests.

Received Feb 17, 2017; Revised Apr 17, 2017; Accepted July 20, 2017. Published Oct 30, 2017

 

 

Abstract

Introduction: The aim of this study is to gather the main results obtained about « Prostate Cancer and EVs », in the six yearly Meetings of the International Society for Extracellular Vesicles (ISEV) from 2012 to 2017, in order to get a leading thread for future research.

Methods: Altogether, 167 abstracts (72 Oral Communications and 95 Posters) dealing with « Prostate » were analyzed and classified as a function of their main respective goal : characterization of the various prostate cancer-derived EVs, search for biomarkers at the proteomics or RNAs levels, influence of prostate cancer-derived EVs from various cell lines upon normal cells, EVs clinical measurements in different human biofluids and in vivo models. New set-ups for sensitive exosome measurements, having a clinical potential for diagnostics, were also reported.

Summary/Conclusion: The main results of this scientific monitoring will be presented. Many interesting observations have already been collected about the characterization and functional properties of prostate cancer cells-derived EVs. However, a better research coordination about EVs potentials for diagnosis, prognosis and therapy of prostate cancer would be worth seeking, with a more defined leading thread for research. The final aim of the paper is to try to interest practicians, deeply involved with prostate cancer, but not yet familiar with the future potentialities of EVs for theranostics of this cancer.

Keywords: Prostate cancer (PCa), extracellular vesicles (EVs), intercellular communication, PCa diagnosis, Castration-Resistant Prostate cancer (CRPC) prognosis