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Review
Cancer Research Frontiers. 2017; 3(1): 72-82. doi: 10.17980/2017.72
Prostate Spinal Metastasis: An Update and Review
Neha Rao1, Abhiraj D. Bhimani1, Steven T. Papastefan1, Pouyan Kheirkhah1, Gregory D. Arnone1, and Ankit I. Mehta1
1 Department of Neurosurgery, University of Illinois at Chicago
*Corresponding author: Ankit I. Mehta, M.D. Assistant Professor and Assistant Program Director, Director of Spinal Oncology, Adjunct Professor Orthopedic Surgery and Chemical Engineering, Department of Neurosurgery, University of Illinois at Chicago. 912 S. Wood Street, 4N NPI, Chicago, IL 60612. Email:
Citation: Neha Rao, et al. Prostate Spinal Metastasis: An Update and Review. Cancer Research Frontiers. 2017; 3(1): 72-82. doi: 10.17980/2017.72
Copyright: @ 2017 Neha Rao, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Competing Interests: The authors declare no competing financial interests.
Received Oct 01, 2016; Revised Aug 15, 2017; Accepted Aug 29, 2017. Published Oct 18, 2017
Abstract:
Advanced prostate metastasis causes significant morbidity and mortality on the adult male population. This paper reviews the evidence regarding the efficacy of various treatment options currently present for patients with metastatic castration-resistant prostate cancer (mCRPC) to the spine. Treatment approaches for prostate spinal metastasis involves a multidisciplinary team. This paper is a review of all the viable treatment options available to patients who present with spinal mCRPC, including discussion on gaps in care and emerging treatments that may both address symptoms as well as facilitate local disease control. Despite multiple modalities of treatment, there is limited data to support a treatment paradigm that provides the most efficacious sequence of approved treatments for individual patients. Future studies that analyze these algorithms are needed to improve prostate metastatic care.
Keywords prostate cancer, spinal metastasis, metastatic castration-resistant prostate cancer, stereotactic radiosurgery, radium-223, Androgen-Deprivation Therapy
