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Cancer Research Frontiers. 2016 Feb; 2(1): 112-125. doi: 10.17980/2016.112

Insight into the mechanisms of endometriosis associated ovarian cancers development

Athanasios Farfaras1*, Max Danielis1, Sofia Papavasileiou1, Stavroula Barbounaki1, Evripidis Bilirakis1, Panagiotis Skolarikos1

1A’ Department of Obstetrics and Gynecology, “Helena Venizelou” Maternal Hospital, Athens, Greece

 

*Corresponding author: Athanasios Farfaras, A’ Department of Obstetrics and Gynecology, “Helena Venizelou” Maternal Hospital, Helena Venizelou square, DC: 11521, Athens, Greece. Tel: +30 2132051000. Email address: farfaras@gmail.com

Citation: Athanasios Farfaras, et al. Insight into the mechanisms of endometriosis associated ovarian cancers development. Cancer Research Frontiers. 2016 Feb; 2(1): 112-125. doi: 10.17980/2016.112

Copyright: @ 2016 Athanasios Farfaras, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Competing Interests: The authors declare no competing financial interests.

Received Nov 29, 2015; Revised Jan 28, 2016; Accepted Feb 11, 2016. Published Mar 10, 2016

 

Abstract

Women suffering from endometriosis face a higher risk for cancer development in ectopic endometrial tissue sites, especially in ovaries. Malignant transformation of endometriotic lesions represents a well know phenomenon, but mechanisms involved remain not entirely understood. However, novel evidences have emerged, improving our understanding of this entity. Genetic alterations, including but not limited to loss of heterozygosity, gene mutations, chromosome amplifications, overexpression of oncogenes, inactivation of tumor suppressor genes, variations in regulating genes and post transcriptional regulation of gene’s expression, contribute to malignant transformation. Genetic instability is in linkage with multiple molecular processes, as production by heme and iron induced oxidative stress, local microenvironment with high concentrations of estrogens and recruitment of inflammation factors. This review summarizes the current knowledge of multileveled mechanisms potentially involved in the pathogenesis of endometriosis associated ovarian cancer.

Key Words: Endometriosis; Endometriosis associated ovarian cancer; Oxidative stress; estrogen

 

 

 

 

 

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