Article

Decreased levels of the serum inflammatory biomarkers, sGP130 , IL-6, sCRP and BAFF, are associated with increased likelihood of AIDS related Kaposi’s sarcoma in men who have sex with men

Rachel Bolanos1,  Otoniel Martinez-Maza 1, 2, 3, 4,  Zuo-Feng Zhang1, Shehnaz Hussain1, 5, Mary Sehl6, 8, Janet S. Sinsheimer 7,8, 9, Gypsyarn D’Souza10, Frank Jenkins11, Steven Wolinsky12, Roger Detels1

1Department of Epidemiology, Fielding School of Public Health, UCLA, Los Angeles, CA 2Departments of Obstetrics and Gynecology, and Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, UCLA, Los Angeles, CA 3Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA  4UCLA AIDS Institute, UCLA, Los Angeles, CA  5Department of Medicine and Comprehensive Cancer Center, Cedars-Sinai Medical Center, West Hollywood, CA  6Department of Medicine, Division of Hematology/Oncology, AIDS Institute, UCLA, Los Angeles, California 7Department of Human Genetics, UCLA, Los Angeles, California 8Biomathematics, David Geffen School of Medicine, UCLA, Los Angeles, California 9Department of Biostatistics, School of Public Health, UCLA, Los Angeles, California 10Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 11University of Pittsburgh Cancer Institute, Pittsburgh, PA 12Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago Illinois

  

Contact information: Rachel Bolanos

4430 Overland Ave. #3, Culver City, CA 90230

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Abstract:

This study investigated the role of inflammatory and immune activating biomarkers in AIDS related Kaposi’s sarcoma in men who have sex with men in the Multicenter AIDS Cohort study between 1984 and 2010. Concentrations of 24 serum biomarkers; IL-1β, IL-2, Il-6, IL-8, IL-10, IL-12p70, sGP130, sIL-2Rα, sIL-6R, eotaxin, MCP-1, MCP4, MIP 1β, TARC, BLC-BCA1, IP-10, GM-CSF, IFN-γ, BAFF, sCD14, CD27, sTNFR-2, sCRP, and TNF-α were obtained longitudinally from 1500 men over 100,000 visits. The concentrations were compared between cases and controls at multiple time points prior to diagnosis or study termination with four markers consistently higher in cases; sIL-2Rα, IP-10, sTNFR-2, MCP-1, and five higher in controls; GM-CSF, IL-6, MIP-1β, sCRP, sGP130.

Logistic regression analyses were run using data from 2-3 years prior to diagnosis for 705 participants; 37 cases and 668 controls. Each biomarker was log transformed and entered into a logistic model adjusted for HBV and HCV co-infection, race/ethnicity, age at last visit, education, smoking and CD4+ cell count. In the adjusted models there were no significant associations between elevated marker concentration and an increased risk. There were four markers that showed significantly lower concentrations correlated with an increased risk including sGP130 (OR=.14, 95% CI = (.03, .73), p=.0197), BAFF (OR=.60, 95% CI = (.16, .90), p=.0282), sCRP (OR=.61, 95% CI = (.43, .87),  p=.0064) and IL-6 (OR=.51, 95% CI = (.35, .76),  p=.0009). It is possible that the difference in biomarker concentrations, in conjunction with other factors, could be indicative of AIDS-KS development in HIV infected men.

 

Key Words: AIDS, Kaposi’s sarcoma, inflammatory biomarkers

 

 

 

 

 

 

 

 

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