Review

Phytomelatonin versus synthetic melatonin in cancer treatments

 

Prof. Dr. Marino B. Arnao

Dr. Josefa Hernández-Ruiz

 

Department of  Plant Physiology. Faculty of Biology.

University of Murcia. 30100-Murcia. Spain

E-mail: marino@um.es

 

Abstract

Melatonin is a molecule with a wide variety of interesting functions in animals. In mammals, it is synthesized by the pineal gland, and other tissues. This endocrine compound has been studied for use in anti-tumor treatments of various kinds. Melatonin seems to play an important role in multiple stages of tumor development, both in growth/proliferation and in apoptosis and metastasis, and also through immunological regulation. While synthetic melatonin is usually used in these studies, this work looks at, an alternative, phytomelatonin, melatonin of plant origin. The interest of this proposal arose from the need to avoid the unwanted by-products present in synthetic melatonin preparations. The substitution of synthetic melatonin by phytomelatonin in medical treatments could also lead to substantial improvements in the results. The application of phytomelatonin in clinical studies is proposed as an objective.

 

Keywords: antioxidant; anti-tumoral; apoptosis; EMS; melatonin; phytomelatonin; 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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