Case report:

Atypical Presentation and Aggressive Evolution of Primary CNS Lymphoma (PCNSL)

 

Karan Topiwala MBBS1,2, Karan Tarasaria MBBS1,2, Jussie Lima MD1,2, Xianyuan Song MD2a, Ahamad Daher MD2b, Amre Nouh MD2

University Of Connecticut School Of Medicine1,, Hartford Hospital2, Department of Neurology, Department of Pathologya, Department of Neuro-Oncologyb

 

Corresponding Author:

Amre Nouh

Hartford Hospital,

Department Of Neurology,

80 Seymour St.,

Hartford, CT 06106, USA

Ph: 860.972.3621

Amre.Nouh@hhchealth.org

 

Abstract

Patients with Primary CNS Lymphoma (PCNSL) typically present with focal neurodeficits with neuroimaging showing a solitary, nonhemorrhagic mass. We describe a 48 year old woman who presented with her first lifetime seizure with no identifiable intracranial mass, who 7 months later, developed focal deficits and was found to have multifocal lesions associated with intracerebral hemorrhage, which on biopsy were consistent with a PCNSL. No case report of a “MRI negative” symptomatic PCNSL has previously been reported.

Keywords: CNS lymphoma, PCNSL, MRI, Intraparenchymal haemorrhage

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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